Persistent Vegetative State
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What is Coma and Persistent Vegetative State?Is there any treatment?What is the prognosis?What research is being done?OrganizationsWhat is Coma and Persistent Vegetative State?
A coma is a profound or deep state of unconsciousness. An individual in a state of coma is alive but unable to move or respond to
his or her environment. Coma may occur as a complication of an underlying illness, or as a result of injuries, such as head
trauma. A persistent vegetative state (commonly, but incorrectly, referred to as "brain-death") sometimes follows a coma. Individuals in such a state have lost
their thinking abilities and awareness of their surroundings, but retain non-cognitive function and normal sleep patterns.
Even though those in a persistent vegetative state lose their higher brain functions, other key functions such as breathing
and circulation remain relatively intact. Spontaneous movements may occur, and the eyes may open in response to external stimuli.
They may even occasionally grimace, cry, or laugh. Although individuals in a persistent vegetative state may appear somewhat
normal, they do not speak and they are unable to respond to commands.
Is there any treatment?
Once an individual is out of immediate danger, the medical care team focuses on preventing infections and maintaining a healthy
physical state. This will often include preventing pneumonia and bedsores and providing balanced nutrition. Physical therapy
may also be used to prevent contractures (permanent muscular contractions) and deformities of the bones, joints, and muscles that would limit recovery for those who
emerge from coma.
What is the prognosis?
The outcome for coma and persistent vegetative state depends on the cause, severity, and site of neurological damage. Individuals
may emerge from coma with a combination of physical, intellectual, and psychological difficulties that need special attention.
Recovery usually occurs gradually, with some acquiring more and more ability to respond. Some individuals never progress beyond
very basic responses, but many recover full awareness. Individuals recovering from coma require close medical supervision.
A coma rarely lasts more than 2 to 4 weeks. Some patients may regain a degree of awareness after persistent vegetative state.
Others may remain in that state for years or even decades. The most common cause of death for someone in a persistent vegetative
state is infection, such as pneumonia.
What research is being done?
The NINDS supports and conducts research on neurological conditions such as coma and persistent vegetative state. This research
is aimed at finding ways to prevent, treat, and cure these conditions.
Select this link
to view a list of studies currently seeking patients.
Organizations
Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by
or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice
on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined
that patient or is familiar with that patient's medical history.
All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.
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Last updated February 12, 2007
