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Subcortical Arteriosclerotic EncephalopathyTable of Contents (click to jump to sections)What is Binswanger's Disease? Is there any treatment? What is the prognosis? What research is being done? Organizations What is Binswanger's Disease? Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists call executive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis. Is there any treatment? There is no specific course of treatment for BD. Treatment is symptomatic. People with depression or anxiety may require antidepressant
medications such as the serotonin-specific reuptake inhibitors (SSRI) sertraline or citalopram. Atypical antipsychotic drugs,
such as risperidone and olanzapine, can be useful in individuals with agitation and disruptive behavior. Recent drug trials
with the drug memantine have shown improved cognition and stabilization of global functioning and behavior. The successful
management of hypertension and diabetes can slow the progression of atherosclerosis, and subsequently slow the progress of
BD. Because there is no cure, the best treatment is preventive, early in the adult years, by controlling risk factors such
as hypertension, diabetes, and smoking.
What is the prognosis? BD is a progressive disease; there is no cure. Changes may be sudden or gradual and then progress in a stepwise manner. BD
can often coexist with Alzheimer's disease. Behaviors that slow the progression of high blood pressure, diabetes, and atherosclerosis
-- such as eating a healthy diet and keeping healthy wake/sleep schedules, exercising, and not smoking or drinking too much
alcohol -- can also slow the progression of BD.
What research is being done? The National Institute of Neurological Disorders and Stroke (NINDS) conducts research related to BD in its laboratories at
the National Institutes of Health (NIH), and also supports additional research through grants to major medical institutions
across the country. Much of this research focuses on finding better ways to prevent, treat, and ultimately cure neurological
disorders, such as BD.
Select this link to view a list of studies currently seeking patients.
Prepared by: NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history. All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated. Last updated August 03, 2007 This information has been provided by The National Institute of Neurological Disorders and Stroke (NINDS). |