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Adrenal insufficiency while taking synthroid
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Adrenal insufficiency while taking synthroid

by tina999, Aug 30, 2005 12:00AM
Hi you guys,



I am a 28 female diagnosed with Hasimoto's.  I am very mildly symptomatic and it was caught by a TSH result of >150.  Positive for the TPO antibodies as well.  



I have twice tried med trials for the hypothyroidism.  The first was 75 ug of levothyroxine.  After five days the side effects got so bad I stopped taking it.  On the sixth day I went to the ER.



The endo tested ACTH, cotisone, aldosterone, TSH and T4 and said my adrenal glands looked fine and she wanted to start at a lower dose and titrate up.  I started at 25 ug for a week then 50 ug for a week.  On the second day at 25 ug the side effects were back and I went to the ER four times in the next two weeks.



I stopped taking the meds on the third day at 50 ug.  The endo brought me in the next day and ran an ACTH stim test which looked fine.  I tested myself for Adrenal antibodies which was negative.



Side effects were nausea, headache, inability to concentrate urine, trembling, muscle weakness, loss of peripheral circulation leading to numbness and no muscle control, and eventually delerium and giddiness with slurred speech and cognitive impairment. (hypovolemic hyponutremia ?) It took two days after the first med trial to feel more normal.  The next time it was much more tramatic to stop taking the thyroid meds as I woke up shaking and very cold or everything getting so slow I thought I was dying.  Also delerius spells through that weekend as (I think) the electrolytes balance was restored.



Off meds now I am fine.  I am at a new endo and he wants to have another med trial. It makes me cry a bit.
Member Comments (8)

by ShannieK, Aug 30, 2005 12:00AM
Hi, I have been going through some similiar ordeals here recently, and have learned as much to know that if you have adrenal insufficiency, that starting thyroid meds, makes it worse.  This is what I have heard and read and been told by my endo.  My only question, is that since you've been tested and everything comes back normal, how is it, that they feel you have the adrenal insufficiency.  See, I too, am being tested over and over again, for adrenal problems, evidentally, everything points in that direction, however all tests come back normal.  Just curious.  Shannon

by Jimlow, Aug 30, 2005 12:00AM
To: Tina999-ShannieK-Ar(long post)
Hi, first Shannon, I went off the forum and still will be for most part. This week I'm involved in patent renewal, of a product myself and five partners have been involved with since 1989. Once so often I look at messages, I wanted to reply to this one.

Tina999, like ShannieK, Ar1281a and you, I had problems with certain symptoms actually WORSENING after starting thyroid replacement. This promted me to search, which led me to the very websites, by the makers of the thyroid meds. They stated that people with UNTREATED adrenal cortical insufficiency (low cortisol), can experience worsening of their low-adrenal symptoms if they start thyroid homone replacement. It also took me to websites like the one by Dr. Shames, which you can find by going to "google.com" or other search engines and put in search-words: "the thyroid adrenal connection". You will be surprized at the info., click on the articles, including by Dr. Shames, very informative!

Some of us have also looked at Mitral Valve Prolapse lately, as another factor in making low adrenal symptoms worse. I believed from the beginning that MVP is only a possible peice of the puzzle and not the root-cause. These other sites state that worse adrenal symptoms after start of thyroid med., "unmasks an adrenal problem". I can relate to every symptom you listed but nausea has been mild and intermittant. Your cognitive symptoms (mental confusion etc...), I call "mind prattle" but this one too is fairly mild with me and mostly just makes things repeat over & over in my mind but does sometimes affect concentration too. I do get episodes of joint pain with mine too.

Shannon can relate to the fact that tests can show abnormal, then suddenly others do not, this even confuses the Docs. Drmark on here commented (very appreciated) on an ACTH Stim. test I got. He said my baseline reading of "10.7", which also doubled at 30pmin, then tripled at 1-hour, was fairy normal HOWEVER, what I didn't get to tell him is that my 24-hour urine test was low like Shannons (mine "10.7"). I also took many saliva cortisol tests, some low-normal, some borderline low and some 'clinically low' but NEVER in mid to upper normal! I think you Tina999, Shannon, Ar and myself, have a type of adrenal problem, very hard to detect because it is not quite full blown like Addison's Disease and there are aggrivating factors (ei:thyroid & MVP etc...). Treatment for less-than-full-blown, carries risk factors Dr.s simply don't want to take with us, understandably. I'm hoping/believing for positive revelations and is precisely why we search about things such as MVP but right now, it seems we are in kind of a "limbo" with this thing. Frustration is very understandable but we MUST keep researching!!!

Thanks Ladies.

by ar1281a, Aug 30, 2005 12:00AM
To: jimlow
Thanks jimlow. I really appreciate your postings and your research skills :-)



Tina999, do you know how your blood pressure was when you had these problems? they sound scary and severe, mine haven't been this bad.



We're all in the same boat in the quest for an answer. Thankfully, we have Drs that are willing to work with us.



Jimlow/Shanniek, I'm going in for the echo this week, my GP agreed that it'd be a possibility and it's better to rule it out.



Take care you all

by tina999, Aug 30, 2005 12:00AM
The docs are at a loss.  The symptoms clinically are those of an electrolyte imbalance and clinically point to aldosterone shortage.  I'll post more a bit later on that.   The tests are normal and then they backtrack and sayy it's adaptation to the thyroid meds.  It is wierd and they don't know what to call it.  I call it adrenal insufficiency.   My adrenals aren't broken but something isn't responding correctly.



Actually the thyroid meds cause my blood pressure to go from 110/70 to about 130/90.    I went in with no peripheral circulation-my hands were white but my blood pressure "looked" okay.   I am so confused.

by ShannieK, Aug 31, 2005 12:00AM
To: jimlow, and Ar
Hi guys, Finally got a hold of the endo today.  My MRI, came back normal on my pituitary gland.  She also did anothr 24 hr urine and cortisol AM blood test, that came back normal.  She tested a third time for aldosterone, testosterone, DHEA, and ACTH, all came back normal, however, as usual my ACTH was high again.  Believe it or not, she is sending me in tomorrow, to have it all tested again for the 4th time, she said if these tests come back normal again, she will pass on the CAT scan of my adrenals, because all seems to look normal after all.  She is going to be focusing more on my Hashi's.  I guess I might just be one of these people that are so sensitive to thryoid treatments and doses.  She said, all comes back normal on my adrenals, except the ACTH, which she says must just be caused by stress cause she is not finding any other abnormality anywhere, besides the fact that I never showed any signs of someone with an insufficiency, except one 24 hr urine on cortisol that came back low, I've had 3 others, that are normal. And I owe alot to you both as well as drmark who suggested the propranolol for the cause of the OI.  I have been suffering from that pressure in my head and everything for a year now.  I stopped taking those meds, and that whole thing went away, I haven't had a problem with it at all today. The other intresting part, is the whole time I was on those meds to control my blood pressure, my pressure always remained high!!!!  now that I have stopped taking the beta blockers, my blood pressure has returned to normal.  does any of this make sense?  I also think I mentioned that I think i've been overmedicated this whole time on my synthroid.  I have suffered from heart palps, chest pain and shortness of breath for one year, not to mention extreme joint pain, and since my last thyroid flare up a week ago, all those symptoms are gone also.  Could it really have been this simple all along?  I know my levels always looked normal, but with me, a .9, really made me feel terrible, the closer it gets to a 2.0, the better I feel.  Just goes to prove that everyone is different.  Keep in touch you guys, I'll let you know how my next tests come out.  Shannon

by tina999, Aug 31, 2005 12:00AM
Hi again you guys,



Jimlow I think I agree with you that we have something rare and wierd about our adrenal glands/ HPA axis.  I have a couple of ideas- high cortisone negatively effects the hypothalamus, causing less CFH and subsequesnt less ACTH to be realesed.  However what detects the low cortisone?  The med books aren't real clear about that.  They say stress causes upregulation but they don't know exactly so can't say. Our adrenal glands aren't broken, but we aren't responding correctly to the drops in cortisone and aldosterone that happen when we start the thyroid hormone.  The HPA axis is pretty complicated and my guess is that our's is misbehaving.  Perhaps our bodies sense the hypo state as "stress".  Constant stress increases cortisol and decreases the response of the hypothalumus to changes in cortisol.  Correcting the hypo state causes a massive clearance of the cortisol but our adrenals don't kick in and spit anymore out leaving us "adrenal insufficeint".  The HPA research is directed mostly at anxiety and depression