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Gastroenterology (Expert Forum)
Dr. Had a wierd look on his face reading test results - liver biopsy
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Dr. Had a wierd look on his face reading test results - liver biopsy
by Tinkerbell8, Apr 18, 2002 12:00AM
36yrs./hbpressure/diabetic/thyroid disea
TestDate: 04/12/2002
Final diagnosis: Mild portal triaditis with areas of imcomplete cirrhosis.
Pre-op Diagnosis: Elevated LFTs; rule out autoimmune hepatitis.
Specimen comments: The inflammatory infiltrate within the lobules is minimal which suggests that the inflamatory component of the process is waning. It is assumed that past inflammation has resulted in the marked areas of fibrosis within the lobules and also accounts for the incomplete cirrhosis which is seen. The differential diagnosis for etioglogies that might cause these microscopic changes include autoimmune hepatitis, quiescent viral hepatitis, alcoholic hepatitis and possibley drug-related liver injury. These finding are nonspecific and clinical correlation is needed.
Microscopic description: Within the portal traids these is a slight increase in the number of chronic inflammatory cells seen. Rare plasma cels and neutrophils are also seen. Bile duct destruction, bile duct proliferation and granulomas are not seen. Interface hepatitis is not present in this sample. Within the lobules there are marked areas of macrovesicular steatosis. Foci of fibrosis are seen in association with hepatocellular dropout. However, hepatocellular necrosis in not seen. Areas of cholestasis are identified. The Prussian blue iron stain does not demonstrate iron within the live parenchyma. The masson's trichrome stain shows fibrous expansion of the portal areas. porta-to-portal bridging, portal-to-cental bridging and areas of incomplete cirrhosis are also seen. No malignancy is identified.
TestDate: 04/12/2002
Final diagnosis: Mild portal triaditis with areas of imcomplete cirrhosis.
Pre-op Diagnosis: Elevated LFTs; rule out autoimmune hepatitis.
Specimen comments: The inflammatory infiltrate within the lobules is minimal which suggests that the inflamatory component of the process is waning. It is assumed that past inflammation has resulted in the marked areas of fibrosis within the lobules and also accounts for the incomplete cirrhosis which is seen. The differential diagnosis for etioglogies that might cause these microscopic changes include autoimmune hepatitis, quiescent viral hepatitis, alcoholic hepatitis and possibley drug-related liver injury. These finding are nonspecific and clinical correlation is needed.
Microscopic description: Within the portal traids these is a slight increase in the number of chronic inflammatory cells seen. Rare plasma cels and neutrophils are also seen. Bile duct destruction, bile duct proliferation and granulomas are not seen. Interface hepatitis is not present in this sample. Within the lobules there are marked areas of macrovesicular steatosis. Foci of fibrosis are seen in association with hepatocellular dropout. However, hepatocellular necrosis in not seen. Areas of cholestasis are identified. The Prussian blue iron stain does not demonstrate iron within the live parenchyma. The masson's trichrome stain shows fibrous expansion of the portal areas. porta-to-portal bridging, portal-to-cental bridging and areas of incomplete cirrhosis are also seen. No malignancy is identified.
Member Comments
by Beaker, Apr 22, 2002 12:00AM
Ask the Doctor about Primary Biliary Cirrhosis. PBC for short. If there is a possibily of this diagnosis, find yourself a Physican who does most of his/her work at a University Hospital. Good Luck!
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