Questions posted in the Neurology and Neurosurgery Forum have been answered by doctors from The Cleveland Clinic Foundation.

Question Title: pituitary hypofunction

Forum: Neurology Forum
Topic: Neurology - General


Could you tell me what the symptoms of hypofunctioning pituitary due to strokes or vascular lesions of the pituitary? what all hormone levels can it affect? TSH ? ACTH ect?? Thanks!!!


=
Thanks for your question. The following are the pituitary hormones that are
most important to the immediate health of a person:

- Vasopressin (Anti-diuretic hormone or ADH): lack of ADH will result in
diabetes insipidus (DI), if which a patient is incapable of preserving
his/her body water due to an inability to "concentrate" the urine. If
the ADH production deficit is permanent, the patient should be treated
with DDAVP (a synthetic form of ADH).

- ACTH: lack of ACTH will result in secondary hypocortisolism, or the deficiency
of glucocorticoids. The symptoms include nause, vomiting, weakness,
fatigue, fever, and hypotension. The treatment is corticoid replacement,
usually with oral prednisone.

- TSH: hypothyroidism will result from lack TSH, and will manifest as
lethargy, weight gain, cold intolerance, constipation.

For pre-menopausal women, a deficiency in LH and FSH without proper replacement
will result in amenorhea, and subsequent sterility.

I hope this information is helpful. Best of luck.

This information is provided for general medical education purposes only.
Please consult your doctor regarding diagnostic and treatment options.



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